From the press release:

This is the biggest change in Peter Parker’s life in years and it’s all happening in Amazing Spider-Man #648, from the new ongoing creative team of fan-favorite Spidey Scribe Dan Slott and red hot artist Humberto Ramos! Spidey’s new status quo starts right here in a story so big we needed a double-sized first issue and a twice-monthly series to tell it!  Peter Parker’s life has reached a crucial turning point, and nothing will ever be the same! New job! New costume! New girlfriend! New Spider-Girl! Big Time is so big that we had to bring The Sinister Six, The Avengers, The Fantastic Four, Mary Jane, Flash Thompson and the all new, all different Spider-Girl together this November, only in Amazing Spider-Man #648!

Preview Pages:

AMAZING SPIDER-MAN #648 (SEP100569)
AMAZING SPIDER-MAN #648 BLANK VARIANT (SEP100570)
AMAZING SPIDER-MAN #648 CASELLI VARIANT (SEP100571)
AMAZING SPIDER-MAN #648 CAMPBELL VARIANT (SEP100572)
AMAZING SPIDER-MAN #648 MARTIN VARIANT (SEP100573)
Written by DAN SLOTT
Pencils and Cover by HUMBERTO RAMOS
Blank Cover Variant Also Available
Variant Cover by STEFANO CASELLI
Spider-Girl Variant Cover by J. SCOTT CAMPBELL
Wraparound Variant Cover by MARCOS MARTIN
Rated A…$3.99
FOC – 10/14/10, On-Sale – 11/10/10

AMAZING SPIDER-MAN #649 (SEP100574)
Written by DAN SLOTT
Pencils & Cover by HUMBERTO RAMOS
Rated A …$3.99
FOC – 10/29/10, On-Sale – 11/24/10

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2. Marvel Unveils Joe Quesada’s Amazing Spider-Man #638 Cover
3. Your First Look at Amazing Spider-Man #638: ‘One Moment in Time’!
4. A Preview of Amazing Spider-Man #634
5. Your First Look at Amazing Spider-Man: Origin of the Species!